The generalizability of the results will allow their application to virtually any previously developed FET-based sensor. We further show that this closed-loop control approach can be extended to commonly used single-gate silicon FETs. We show how high-performance dual-gate 2D FETs that we recently developed, when operated using closed-loop proportional–integral–derivative control, can drastically improve both the sensitivity and resolution. We review the state-of-the-art instrumentation in the field as applied to sensing with FETs. We show that instrumentation that is commonly used in multiple areas of physics and engineering can greatly improve the performance of measurement systems that embed FET-based transducers for biological applications. Most research studies in this field focused on building discrete devices with high performance. The reported techniques can also be applied to other fields relying onįunctionalized GFETs, such as gas or chemical sensing or infrared imaging.Field-effect transistors (FETs) are powerful tools for sensitive measurements of numerous biomarkers (e.g., proteins, nucleic acids, and antigen) and gaseous species.
This platform offers a truly statisticalĪpproach on GFET based biosensing and further to quantitative and multi-analyte Of the sensing platform array with 512 GFETs in simultaneous detection for As an important step towards that, we report wafer-scaleįabrication of CMOS integrated GFET arrays with high yield and uniformity,ĭesigned especially for biosensing applications. Nanomaterials, are among the most promising technologies for label-freeĮlectrical biosensing. Such multiplexed bioassays, whether based on graphene or on other sensitive Statistics require sensor arrays with reduced variability in functionalization. Towards truly quantitative sensors and on-chip bioassays with improved Reliability and require increased statistics. The next steps in industrialization relate to improving The development of CMOSīack end of line integration compatible graphene field-effect transistor (GFET)īased biosensing has been rapid during the last few years, both in terms of theįabrication scale-up and functionalization towards biorecognition from real Readout electronics and extremely large sensor counts.
Solutions, offering miniaturized multiplexed sensing arrays with integrated Greatly from complementary metal-oxide semiconductor (CMOS) integrated sensing Towards multiplexed multianalyte detection. Point-of-care diagnostics are transitioning from single analyte detection Download a PDF of the paper titled Wafer-scale graphene field-effect transistor biosensor arrays with monolithic CMOS readout, by Miika Soikkeli and 12 other authors Download PDF Abstract: The reliability of analysis is becoming increasingly important as
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